pakapk4 CKAP4 Antibody (A-3 - CKAP4 uniprot DKK1‐CKAP4 signaling axis promotes cancer growth and tumorigenesis Understanding CKAP4: A Multifaceted Protein in Cellular Function and Disease

CKAP4 uniprot CKAP4, also known by its synonyms CLIMP-63 and p63, is a type II transmembrane protein encoded by the CKAP4 geneCKAP4 Antibody (A-3) is a mouse monoclonal IgG1 κ CKAP4 antibody, cited in 2 publications, provided at 200 µg/ml; raised against amino acids 513-602 mapping  Initially identified as an endoplasmic reticulum protein, extensive research has revealed its dynamic localization and diverse functions within the cell, extending to the plasma membrane and playing crucial roles in various biological processes, including cellular structure, disease progression, and as a potential biomarkerNewly developed humanized anti-CKAP4 antibody This article delves into the multifaceted nature of CKAP4, drawing upon scientific literature and AI big data to provide a comprehensive overview of its significance作者：H Kimura·2019·被引用次数：139—CKAP4 secreted in exosomes may represent a biomarker for PDAC. Anti-CKAP4 mAbs can contribute to the development of novel diagnostic methods 

Cellular Roles and Interactions of CKAP4

CKAP4 is intrinsically linked to cellular architecture and functionAddressed to John Amphett Clent Cambridge. He was Squire of Clent and wrote A Short History of Clent. Lived 1845 to 1918. It is known to anchor the endoplasmic reticulum to microtubules, a critical interaction for maintaining the integrity and organization of the cellular machinery作者：H Tan·2021·被引用次数：19—The present study aimed to investigate the role ofCKAP4in tryptase-induced atrial fibroblast activation, atrial fibrosis, and molecular  Furthermore, CKAP4 possesses the ability to bind RNA, indicating a role in post-transcriptional gene regulation作者：H Kimura·2016·被引用次数：205—Here, we identified cytoskeleton-associated protein 4 (CKAP4) as a DKK1 receptor and evaluatedCKAP4-mediated DKK1 signaling in cancer cell proliferation. Its presence in diverse cellular compartments, including the lipid droplet, nuclear speck, and the rough endoplasmic reticulum, underscores its versatility作者：T Luo·2021·被引用次数：9—Cytoskeleton-associated protein 4 (CKAP4)promotes malignant progression of human gliomasthrough inhibition of the Hippo signaling pathway.

A significant discovery regarding CKAP4's function is its role as a high-affinity epithelial cell surface receptor for APF (Amphiregulin)British Post Card 1874 with very interesting writing????😎🍺 This interaction highlights CKAP4's involvement in cell signalingDKK1‐CKAP4 signal axis promotes hepatocellular Moreover, CKAP4 has been identified as a Dickkopf1 (DKK1) receptor2025914—Cytoskeleton-associated protein 4 (CKAP4)promotes malignant progression of human gliomasthrough inhibition of the Hippo signaling pathway. This discovery is particularly important as the DKK1-CKAP4 signaling axis has been implicated in promoting cancer cell proliferation and tumor growth作者：T Luo·2021·被引用次数：9—Cytoskeleton-associated protein 4 (CKAP4)promotes malignant progression of human gliomasthrough inhibition of the Hippo signaling pathway. Research indicates that this pathway is activated in a range of malignant tumors, including pancreatic, lung, esophageal, and liver cancersNewly developed humanized anti-CKAP4 antibody

CKAP4 in Disease Pathogenesis

The involvement of CKAP4 in disease is a burgeoning area of researchEnables RNA binding activity. Located in several cellular components, including lipid droplet; nuclear speck; and rough endoplasmic reticulum. Its role in promoting the malignant progression of human gliomas, for instance, has been extensively studiedCkap4 cytoskeleton-associated protein 4 [ (house mouse)] This progression is linked to the inhibition of the Hippo signaling pathway by CKAP4Anti-CKAP4 antibody produced in rabbitPrestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody; Synonyms CLIMP-63,ERGIC-63,P63 at  In chronic kidney disease (CKD), CKAP4 is understood to contribute to vascular calcification (VC) by modulating YAP phosphorylation and MMP2作者：T Luo·2021·被引用次数：9—Cytoskeleton-associated protein 4 (CKAP4)promotes malignant progression of human gliomasthrough inhibition of the Hippo signaling pathway.

The protein's role extends to cardiovascular health, where CKAP4 is involved in tryptase-induced phenotypic conversion in atrial fibroblasts through the PAR2/p38/JNK pathwayCKAP4 Antibody (A-3) | SCBT - Santa Cruz Biotechnology This finding suggests potential therapeutic targets for conditions affecting atrial function作者：H Kimura·2016·被引用次数：205—Here, we identified cytoskeleton-associated protein 4 (CKAP4) as a DKK1 receptor and evaluatedCKAP4-mediated DKK1 signaling in cancer cell proliferation.

CKAP4 as a Biomarker and Therapeutic Target

The dynamic nature and involvement of CKAP4 in disease processes have positioned it as a promising biomarker and therapeutic targetPkaapk Pakapkis on Facebook. Join Facebook to connect with Pkaapk Pakapk and others you may know. Facebook gives people the power to share and makes the Notably, CKAP4 may represent a novel biomarker and molecular target for lung cancer作者：M Despotidis·2025—CKAP4, originally identified as an endoplasmic reticulum protein, has been found to localize on the plasma membrane and function as a  Studies suggest that a combination therapy involving an anti-CKAP4 antibody and osimertinib could offer a new approach for treating certain lung adenocarcinomas, particularly in cases of EGFR-TKI resistance作者：K Iguchi·2023·被引用次数：19—In hepatocellular carcinoma, theDKK1‐CKAP4 signaling axis promotes cancer growth and tumorigenesis. Combination with anti‐CKAP4 Abs enhances the antitumor 

Furthermore, CKAP4 secreted in exosomes may represent a biomarker for PDAC (Pancreatic Ductal Adenocarcinoma)Anti-CKAP4 antibody produced in rabbit The identification of CKAP4 as a DKK1 receptor has paved the way for developing novel diagnostic methods using anti-CKAP4 monoclonal antibodies (mAbs)CKAP4 Antibody (A-3) is a mouse monoclonal IgG1 κ CKAP4 antibody, cited in 2 publications, provided at 200 µg/ml; raised against amino acids 513-602 mapping  The DKK1-CKAP4 signaling axis actively promotes hepatocellular carcinoma growth and tumorigenesis, and combination therapy with anti-CKAP4 Abs can enhance antitumor effects作者：K Iguchi·2023·被引用次数：19—In hepatocellular carcinoma, theDKK1‐CKAP4 signaling axis promotes cancer growth and tumorigenesis. Combination with anti‐CKAP4 Abs enhances the antitumor  This reinforces CKAP4 as a potential therapeutic target to overcome resistance mechanisms in various cancersCKAP4 is a potential exosomal biomarker and therapeutic Ongoing research into developing newly developed humanized anti-CKAP4 antibodies further underscores its therapeutic potentialDKK1‐CKAP4 signal axis promotes hepatocellular

Research Reagents and Availability

For researchers exploring the intricacies of CKAP4, various reagents are availableCKAP4 participates in tryptase-induced phenotypic These include antibodies such as the CKAP4 Antibody (A-3), a mouse monoclonal IgG1 kappa antibody raised against specific amino acids of CKAP4, and an anti-CKAP4 antibody produced in rabbitCytoskeleton-associated protein 4 - Mus musculus (Mouse) These antibodies are valuable tools for immunoprecipitation, Western blotting, and immunohistochemistry, aiding in the elucidation of CKAP4's cellular localization and interactionsCKAP4 Rabbit pAb - The Sanger Lab Commercial entities like Santa Cruz Biotechnology and Atlas Antibodies are recognized suppliers of such research toolsCytoskeleton-associated protein 4 - Mus musculus (Mouse)

Conclusion

CKAP4 is a protein with a profound impact on cellular biology and a growing significance in pathological conditionsAnti-CKAP4 antibody produced in rabbit From its foundational role in maintaining cellular structure and organelle interactions to its emergent function as a receptor for signaling molecules like DKK1 and its potential as a diagnostic and therapeutic target in various cancers and other diseases, CKAP4 warrants continued scientific investigation作者：H Kimura·2016·被引用次数：205—Here, we identified cytoskeleton-associated protein 4 (CKAP4) as a DKK1 receptor and evaluatedCKAP4-mediated DKK1 signaling in cancer cell proliferation. Understanding the complex roles of this protein, from its expression patterns to its interaction networks, is crucial for developing innovative treatments and improving patient outcomesPkaapk Pakapkis on Facebook. Join Facebook to connect with Pkaapk Pakapk and others you may know. Facebook gives people the power to share and makes the