bet v Bet v - Betvictor 亚洲 Bet v Understanding Bet v 1: The Major Birch Pollen Allergen and Its Implications

Betv1 allergen Bet v 1 is a name that resonates with many individuals who suffer from seasonal allergies, particularly those triggered by birch pollenTargeting immunodominant Bet v 1 epitopes with As the major allergen in birch pollen (Betula verrucosa), this protein is a primary culprit behind the uncomfortable and sometimes severe allergic reactions experienced by millions worldwide during springtimeAnti-Bet v1/AllergenBet vI-A Antibody (SAA0664). Catalog # RZZ02010 Specific References (0) DATASHEET. Host species Human Isotype IgG1 Applications  Understanding Bet v 1 involves delving into its molecular nature, its role in allergic responses, and the ongoing research aimed at mitigating its impactBirch pollen allergen Bet v 1 Recombinant Protein

The Molecular Identity of Bet v 1

Bet v 1 belongs to a family of proteins known as PR-10 proteins (pathogenesis-related proteins) These are generally cytoplasmic proteins with a molecular weight typically ranging from 15 to 17 kilodaltons (kd), and they are widely distributed among dicotyledonous plantsImmunoglobulin E antibodies to theBet v2a profilin protein have been reported in 10% to 38% of birch pollen-allergic patients. Birch pollen is highly  The structure of Bet v 1 has been meticulously studied, with X-ray crystallography and NMR revealing intricate details about its molecular surface These studies have identified three distinct regions on the protein that are predicted to harbor cross-reactive B-cell epitopesBet v2 is a profilin protein of 13–14.4 kDa molecular weight and is a minor allergen of birch (Betula verrucosa) pollen. Approximately 10% of patients allergic  These epitopes are crucial because they are the specific sites on the allergen that the immune system recognizes, leading to the production of IgE antibodies in allergic individuals作者：Y Yamada·2020·被引用次数：21—Here, we established a rapid and robust method for the production ofBet v1 in Nicotiana benthamiana leaves, with binding activity to allergic patients' IgE. The structure of Bet v 1 provides a foundational understanding for developing targeted therapeutic interventionsBet v 1

Bet v 1 and Cross-Reactivity

A significant aspect of Bet v 1's allergenicity lies in its cross-reactivityDocuments Plant Major Pollen AllergenBet v1-A (BETVIA) Protein is a recombinant protein expressed in E. coli from Betula pendula (European white birch) (  Not only does it cause allergies to birch pollen, but it also exhibits structural similarities to major pollen allergens found in taxonomically related treesX-ray and NMR structure of Bet v 1, the origin of birch This means that individuals allergic to birch pollen may also react to homologues of Bet v 1 found in other plantsBet v1 is the most abundant white birch pollen protein (Betula verrucosa). It is a protein belonging to the PR-10 family (proteins related to pathogenicity)  For instance, Bet v 1 homologues in strawberry have been identified as IgE-binding proteins, indicating a potential for cross-reactivity with certain foodsTargeting immunodominant Bet v 1 epitopes with This phenomenon is a key consideration in diagnosing and managing allergies, as symptoms might arise from exposure to various sources beyond just birch pollen佛历2540917—The structure shows three regions on the molecular surface predicted to harbour cross-reactive B-cell epitopes which provide a structural basis  Researchers are actively investigating these cross-reactive proteins, such as Bet v 2 (a profilin protein), which is a minor allergen in birch pollen, and Bet v 4, a calcium-binding protein found in birch pollent216 Bet v 2

The Science Behind Allergy and Bet v 1

The immune system's response to Bet v 1 is mediated by Immunoglobulin E (IgE) antibodies作者：AL Karlsson·2004·被引用次数：74—Results Several IgE-binding proteins could be detected. In more than half of the patient sera, a 20/18-kDa doublet band was observed in Western blotting. These  In sensitized individuals, exposure to Bet v 1 triggers the release of histamine and other inflammatory mediators, leading to the characteristic symptoms of hay fever, such as sneezing, itching, watery eyes, and nasal congestionVBET Online Sports Betting and Casino With the Best Odds For some, these allergies can be severe, impacting their quality of life significantlyDocuments Plant Major Pollen AllergenBet v1-A (BETVIA) Protein is a recombinant protein expressed in E. coli from Betula pendula (European white birch) ( 

Recent scientific advancements have focused on developing novel approaches to combat Bet v 1-induced allergiesBETV2 - Overview BET v2 (Profilin), IgE, Serum For example, a novel antibody cocktail targeting Bet v 1 has shown promise in sustainably treating birch allergy symptoms in early-stage studiesImmunoglobulin E antibodies to theBet v2a profilin protein have been reported in 10% to 38% of birch pollen-allergic patients. Birch pollen is highly  This approach aims to neutralize the allergen by targeting its immunodominant epitopesPlant Major Pollen Allergen Bet v 1-A (BETVIA) Protein By combining monoclonal antibodies (mAbs) that bind to these critical sites on Bet v 1, researchers are working towards preventing the allergic response altogether作者：P Gevaert·2022·被引用次数：73—Novel antibody cocktail targetingBet v1 rapidly and sustainably treats birch allergy symptoms in a phase 1 study Another avenue of research involves the production of recombinant Bet v 1 proteinsHigh-Yield Production of the Major Birch Pollen Allergen This purified birch pollen allergen Bet v 1 recombinant protein can be used in research settings to better understand the allergen's properties and to develop diagnostic tools and immunotherapiesVBET Online Sports Betting and Casino With the Best Odds For instance, methods for high-yield production of the major birch pollen allergen Bet v 1 have been established, facilitating further scientific inquiryAnti-Bet v1/AllergenBet vI-A Antibody (SAA0664). Catalog # RZZ02010 Specific References (0) DATASHEET. Host species Human Isotype IgG1 Applications 

Research and Future Directions

The scientific community continues to explore various facets of Bet v 1Bet v I/Major latex protein (IPR000916) - InterPro entry This includes cataloging its sequences, with extensive series of Bet v 1 sequences added to databases for comprehensive analysisThis antibody binds toBet v1 via an epitope commonly used by allergogenic IgE. Fab versions of this antibody have been used in co-crystallization studies of  The Immune Epitope Database also provides detailed information on Bet v 1 (UniProt:P15494), listing its numerous epitopes that have been extensively studiedX-ray and NMR structure of Bet v 1, the origin of birch The availability of specific antibodies, such as Anti-Bet v 1 [BV16] and Anti-Bet v 1/Allergen Bet v IA Antibody (SAA0664), further aids researchers in their investigationsThis antibody binds toBet v1 via an epitope commonly used by allergogenic IgE. Fab versions of this antibody have been used in co-crystallization studies of 

The ongoing research into Bet v 1 aims to provide more effective diagnostics and treatments for birch pollen allergiesPSC-24-904 · Share · Click to email a link to a friend (Opens in new window) Email · Click to share on X (Opens in new window) X · Click to share on Facebook (  By understanding the molecular mechanisms of allergenicity and cross-reactivity, scientists are paving the way for innovative solutions to alleviate the burden of this common allergyNovel antibody cocktail targeting Bet v 1 rapidly and